High doses of lidocaine as a constant rate infusion in propofol/fentanyl anaesthetized sheep: cardiorespiratory effects
de Mattos-Junior, EwaldoHumberto Hamad Minervino, AntonioAlves Barrêto-Júnior, RaimundoAugusto Mazzocca Lopes Rodrigues, FredericoAkiko Sato Cabral Araújo, CarolinaLippi Ortolani, EnricoRenata Gaido Cortopassi, Silvia
The aim of this study was to investigate the cardiorespiratory and anesthetic-sparing effects of a highdose CRI of lidocaine (200 ?g/kg/min) administered with a propofol/fentanyl regimen to sheep. Twelve adult, castrated male sheep (BW= 32.1 ± 4.9 kg), were used in a prospective, randomized clinical trial. All animals were premedicated with xylazine (0.05 mg/kg, i.m.). Animals in the GPF group were induced with propofol (3 mg/kg) and fentanyl (2.5 ?g/kg) intravenously, and anesthesia was maintained with a CRI of propofol (500 ?g/kg/min) and fentanyl (0.15 ?g/kg/min). In the GPFL group, animals were induced with propofol (3 mg/kg), fentanyl (2.5 ?g/kg) and lidocaine (2.5 mg/kg) intravenously, and anesthesia was maintained with a CRI of propofol (500 ?g/kg/min), fentanyl (0.15 ?g/kg/min) and lidocaine (200 ?g/kg/min); after ten minutes of anesthesia, the propofol dose was reduced by 25% (from 500 ?g/kg/min to 375 ?g/kg/min). Cardiorespiratory parameters were recorded from 15 minutes after preanesthetic medication administration (T0) to the end of the anesthetic procedure (T7). The time points were as follows: T0 15 minutes after preanesthetic medication administration; T1 after anesthesia induction and orotracheal intubation; T2 15 minutes of anesthesia; T3 during traction on the liver; T4 during bowel clamping; T5 during muscle suture; T6 at the end of skin suture;
Texto completo