Gene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected with Helicobacter pylori

Caleman Neto, Agostinho; Rasmussen, Lucas T; Labio, Roger W de; Queiroz, Valdeir F de; Smith, Marília de A C; Viani, Gustavo A; Payão, Spencer L M

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Gene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected with Helicobacter pylori

Caleman Neto, AgostinhoRasmussen, Lucas TLabio, Roger W deQueiroz, Valdeir F deSmith, Marília de A CViani, Gustavo APayão, Spencer L M

Epidemiological investigations have indicated that Helicobacter pylori induces inflammation in the gastric mucosa regulated by several interleukins. The genes IL1B and IL8 are suggested as key factors in determining the risk of gastritis. The aim of this paper was to evaluate the association of gene polymorphism of interleukin-1 and interleukin-8 with chronic gastrits in H. pylori infected patients. A total of 60 patients underwent endoscopic procedure. Biopsy samples were collected for urease test, histopathological and molecular exams. The DNA of theses samples was extracted for detection of H. pylori and analysis of the genes mentioned above. Patients with gastritis had a higher frequency of H. pylori-positive samples.(AU)