Lafora's disease in a free-ranging toco toucan (Ramphastos toco) with neurologic disease

Santana, Clarissa HelenaOliveira, Ayisa RodriguesSouza, Lucas dos Reis deCarvalho, Thaynara Parente dePereira, Fernanda Mara Aragão MacedoSilva, Laice Alves daPimentel, Samantha PinheiroSantos, Daniel Oliveira dosSoares-Neto, Lauro LeiteCourbilly, Andressa QuinaliaSilva, Jéssica Magalhães daPaixão, Tatiane Alves daSantos, Renato Lima

Lafora's disease is a genetic disease associated to mutations in genes that encodes laforin and malin, which results in intracellular polyglucan storage. The present report describes a case of Lafora's disease in a toco toucan with episodes of incoordination and myoclonus that resulted in traumatic lesions and fracture of the left hindlimb. The bird was euthanized and submitted to necropsy. Microscopically there were abundant PAS-positive and diastasis-resistant Lafora's inclusion bodies in neurons in the cerebellum, supporting the diagnosis of Lafora's disease.(AU)

1. Lafora body
2. wild bird
3. neurodegeneration
4. neurodegenerative disease