Chronic gastrointestinal inflammation in a dog mimicking human russell body gastroduodenitis

Cervone, MarioDuboy, JulieLaprie, CarolineAbadie, Jérôme

Herein we describe an unusual benign chronic gastroduodenal inflammation associated with protein losing enteropathy in a dog. A 10-year-old Golden Retriever dog was presented for chronic weight loss associated with pica, ptyalism, vomiting and diarrhea. Blood chemistry showed hypoproteinaemia and hypoalbuminaemia. Gastric and duodenal full-thickness biopsies were collected and histopathological examination revealed severe mucosal infiltration with Mott cells, consistent with Russell body gastroduodenitis in humans. Warthin-starry stain showed no Helicobacterspp. proliferation in gastric biopsies. After treatment includinganti-acid, antibiotics and corticosteroids, no recurrence of gastrointestinal signs was reported and improvement in clinical and biological condition was observed.(AU)

1. IBD
2. Mott cell
3. Russell bodies
4. plasma cell