Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus
Caldas, Lúcio AyresFreitas, Tânia Rosária PereiraAzevedo, Renata CamposSouza, Wanderley de
Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A1 inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5 µg/mL). Light and electron microscopy of infected cells shows that Prostaglandin A1 also prevents virus-induced vacuolization, but at higher concentrations (10 µg/mL).(AU)
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