Mapping of the continuous epitopes displayed on the Clostridium perfringens type D epsilon-toxin

Alves, Guilherme GuerraMachado-de-Ávila, Ricardo AndrezChávez-Olórtegui, Carlos DelfinSilva, Rodrigo Otávio SilveiraLobato, Francisco Carlos Faria

Abstract The epsilon toxin, produced by Clostridium perfringens, is responsible for enterotoxemia in ruminants and is a potential bioterrorism agent. In the present study, 15 regions of the toxin were recognized by antibodies present in the serum, with different immunodominance scales, and may be antigen determinants that can be used to formulate subunit vaccines.

1. Toxin
2. Mapping
3. Epitope
4. Epsilon
5. Enterotoxemia