Anti dermatophytic therapy: prospects for the discovery of new drugs from natural products

Arantes Soares, Lucianade Cássia Orlandi Sardi, JanaínaPatrícia Gullo, Fernandade Souza Pitangui, NaylaScorzoni, LilianaSangalli Leite, FernandaJosé Soares Mendes Giannini, MariaMarisa Fusco Almeida, Ana

Millions of people and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which only infect keratinized structures. With the appearance of AIDS, the incidence of dermatophytosis has increased. Current drug therapy used for these infections is often toxic, long-term, and expensive and has limited effectiveness; therefore, the discovery of new anti dermatophytic compounds is a necessity. Natural products have been the most productive source for new drug development. This paper provides a brief review of the current literature regarding the presence of dermatophytes in immunocompromised patients, drug resistance to conventional treatments and new anti dermatophytic treatments.

1. synthetic product
2. natural products
3. filamentous fungi
4. dermatophytes