Cancer drugs inhibit morphogenesis in the human fungal pathogen, Candida albicans

Routh, Madhushree MChauhan, Nitin MKaruppayil, S Mohan

Candida infections are very common in cancer patients and it is a common practice to prescribe antifungal antibiotics along with anticancer drugs. Yeast to hyphal form switching is considered to be important in invasive candidiasis. Targeting morphogenetic switching may be useful against invasive candidiasis. In this study, we report the antimorphogenetic properties of thirty cancer drugs.(AU)

1. Cancer drugs
2. Antifungal antibiotics
3. Candida albicans
4. Morphogenetic switching