Viability of stressed Mycobacterium tuberculosis and association with multidrug resistance

Conceição Martins, MariaMaria Saraiva Giampaglia, CarmenChimara, EricaSiqueira Oliveira, RosângelaVedovello, DanielleMiyoshi Sakamoto, SidneiFerrazoli, Lucilaine

This study investigated biological characteristics of recovered stressed M. tuberculosis isolates that failed to grow in differential culture media for phenotypic identification and in culture media containing anti-tuberculosis drugs for drug-susceptibility testing, despite of having grown in primary culture. It represents an improvement in the diagnosis of MDR tuberculosis and tuberculosis control.(AU)

1. spoligotyping
2. Mycobacterium
3. multidrug resistance
4. culture growth