Detection of quinolone-resistance mutations in Salmonella spp. strains of epidemic and poultry origin

Souza, Roberta Barreiros deMagnani, MarcianeFerrari, Rafaela GomesKottwitz, Luciana Bill MikitoSartori, DanieleTognim, Maria Cristina BronharoOliveira, Tereza Cristina R. M. de

Mutations into codons Aspartate-87 (62%) and Serine-83 (38%) in QRDR of gyrA were identified in 105 Salmonella strains resistant to nalidixic acid (94 epidemic and 11 of poultry origin). The results show a high incidence of mutations associated to quinolone resistance but suggest association with others mechanisms of resistance.

1. Quinolone Resistance Determining Region (QRDR)
2. gyrA
3. AS-PCR-RFLP
4. Quinolones