Mechanism of bactericidal activity of Silver Nitrate - a concentration dependent bi-functional molecule

Ram Kumar Pandian, SureshbabuDeepak, VenkataramanKalishwaralal, KalimuthuDepartment of Electron microscopy) Viswanathan, PushpaGurunathan, Sangiliyandi

Silver nitrate imparts different functions on bacteria depending upon its concentration. At lower concentration it induced synthesis of nanoparticles, whereas at higher concentrations it induced cell death. Bacillus licheniformis was used as model system. The MIC was 5 mM, and it induced catalase production, apoptotic body formation and DNA fragmentation.

1. Bacillus licheniformis
2. Silver nitrate
3. apoptosis
4. nanoparticle synthesis
5. DNA fragmentation