Atividade antibacteriana de nanopartículas de polipirrol diante de Staphylococcus aureus isolados de amostras de leite de vacas e cabras com mastite

Acosta, A. CSantos, A. SSilva, F. A. GMedeiros, E. SOliveira, H. P. deCosta, M. MFernandes, A. W. CPinheiro Júnior, J. WMota, R. A

The aim of the present study was to evaluate the antibacterial behavior of polypyrrole nanoparticles (PPy-NPs) in water against biofilm producer or not S. aureus isolated from cows and goats with mastitis. One hundred and thirty-eight isolates of S. aureus were initially evaluated for biofilm formation by spectrophotometry in microplates. In addition, the minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) of PPy-NPs in water for planktonic S. aureus were determined. From the bovine samples analyzed, 5 (4.46%) S. aureus isolates showed a strong biofilm production, 17 (15.18%) moderate production, 36 (32.14%) with weak production and 54 (48.21%) did not produce biofilms. Strains from goats (26) showed no biofilm production in 18 (69.23%) strains and weak biofilm production in 8 (30.76%) strains. The MIC and MBC of S. aureus to PPy-NPs were found in the same concentration (125搭/mL) in all strains tested, regardless of biofilm production or not. This finding provides a new insight into the interaction between PPy-NPs and S. aureus, and will offer potential benefits for the control of mastitis.(AU)

1. polymer composite
2. composto de polímero
3. biofilme
4. intramammary infection
5. infecção intramamária
6. biofilm
7. S. aureus