Hypoglycemic, hypolipidemic and antioxidant potential of Myrcia pubipetala in an animal model of type 1 diabetes

Vieira, Bruna MariaGolineli, Ana Luiza de MoraesWiggers, BrendaWayszceyk, SheilaPauleti, Nathielli NayaraAlberton, Michele DebiasiLima, Daniela Delwing deHerkenhoff, Kauê VilmarDal Magro, Débora Delwing

Myrcia genus plants, like Myrcia pubipetala, traditionally used as hypoglycemic agents, hold promise for Type 1 Diabetes Mellitus (DM1) research but need more comprehensive chemical and pharmacological investigation. This is an experimental study involving controlled administration of treatments to a group of rats to assess their effects compared with a control group, investigating the effects of M. pubipetala on alloxan-induced Type 1 Diabetes Mellitus in rats. After the induction of diabetes, the rats received the hydroalcoholic extract (HAE) or aqueous fraction (AF) (25, 50, 100, or 150 mg kg-1) of M. pubipetala, or water. The results showed that diabetic rats presented cell damage in kidneys, oxidative stress, and high levels of glucose and triglycerides in their plasma and erythrocytes. The HAE (150 mg kg-1), per se, reduced lipid and protein oxidation, and the AF (150 mg kg-1) decreased lipoperoxidation. AF (150 mg kg-1), per se, decreased triglyceride levels. Conclusion: treatment with HAE and AF reduced oxidative damage, positively modulated antioxidant defenses, and exerted hypoglycemic and hypolipidemic effects, representing a potential adjuvant treatment for diabetes.(AU)

1. oxidative stress
2. diabetes mellitus
3. Myrtaceae