Correlação citológica e histopatológica do osteossarcoma rico em células gigantes em felino
Jaretta, Tâmara de AlmeidaPaganini, Maria Carolina MarcariniPinto, Ana Carolina de JesusSilva, Halana do CarmoFlecher, Mayra CunhaHorta, Rodrigo dos Santos
Background: Primary bone tumours are uncommon and poorly reported in cats but osteosarcoma (OSA) is the most frequent, mostly inelderly animals. Giant cell-rich OSA is considered rare in the literature representing 3% of all OSA in humans. The mitotic index seemsto have a significant effect on the survival time of cats affected by OSA as well as the tumour histopathological grade. The objective ofthis study was to report the cytological and histopathological findings of a giant cell rich OSA in a 4-year-old cat with persistent felineleukaemia virus (FeLV) antigenaemia.Case: A 4-year-old male neutered cat was referred with a history of persistent FeLV viraemia and pelvic limb lameness with a firmswelling. Previous radiographs of the affected limb revealed bone lysis in the third and fourth metatarsals and increased soft tissueradiopacity in the tarsal region. The referral veterinary assumed it to be osteomyelitis and initiated clinical treatment with antibiotic andanti-inflammatory. The cat was referred after there was no response to medical treatment. The cat was presented with a 5cm diameterulcerated mass, with putrid odor in the pelvic limb. Complementary exams were performed, and abnormalities were found, includingincreased urea, creatinine, calcium and potassium, and decreased sodium and phosphorus. A new radiograph showed exuberant boneproliferation, with increased radiopacity involving tarsal, metatarsal, distal third of tarsal I and II, and distal diaphysis of metatarsal V,without compromising the metaphyseal region of distal diaphysis of metatarsal IV. Chest radiographs and abdominal ultrasound wereunremarkable. Fine-needle aspiration was performed for cytological analysis and revealed a moderate amount of pleomorphic mesenchymal cells with moderate adhesion, cytoplasm with a format ranging from fusiform to stellate, pronounced...(AU)
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