Comparison of the effects of isoflurane and sevoflurane general anaesthesia after induction by propofol on clinical and physiological measurements in calves
Yakan, SelvinazAksoy, Ozgur
Background: In veterinary surgical operations for cats and dogs, inhalation anaesthesia is known to be a good option forgeneral anaesthesia in long operations or emergency cases. Studies have revealed that during inhalation anaesthesia, theheart and respiratory functions of the animals are more stable compared to injectable anaesthesia. However, there are fewstudies performed with the use of inhalation anaesthesia in ruminants. In this research, the goal is to evaluate the effectsof isoflurane and sevoflurane after induction with propofol in calves based on clinical and physiological parameters andto find a more reliable strategy for general anaesthesia in ruminants.Materials, Methods & Results: The research was carried out on 30 calves, from new-born up to 3-month-old, undergoingsurgery operation. Each group consisted of 15 animals that were divided as isoflurane and sevoflurane. For premedication,atropine was administered at a dose of 0.04 mg/kg via subcutaneous injection in calves. For induction, 15 min after atropineapplication, propofol was given at 5-6 mg/kg via intravenous infusion. Then, endotracheal intubation was performed andinhalation anaesthesia began at 5 min after induction. In the isoflurane group, the onset of anaesthesia concentration wasset to 3-5% and the maintenance was set to a concentration of 1.5-3%. In the sevoflurane group, the onset of anaesthesiaconcentration was set to 5-7% and the maintenance was set to a concentration of 2.5-4%. To monitor the calves, the heartrate (HR), the pulse rate (PR), the systolic blood pressure (SBP), the diastolic blood pressure (DBP), the respiratory rate(RR), the rectal temperature (RT) and the electrocardiogram (ECG) measurements were recorded before anaesthesia, thepremedication, the induction periods, at 5, 15, 30, 45, 60, and 75 min after the onset of inhalation anaesthesia during theoperation period. Blood samples were taken before anaesthesia, premedication, induction periods...(AU)
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