Pathological changes of urinary system in a dog with urolithiasis and renal papillary necrosis
Kutlu, TuncerYücel-Tenekeci, GözdePekcan, MertKule, Emir YengiKutsal, Osman
Background: Urolithiasis is one of the important lower urinary tract diseases in dogs. Uroliths develop when urine becomessupersaturated. Struvite urolithiasis in dogs is formed when urine saturated with magnesium, ammonium and phosphate.Renal papillary necrosis is a form of nephropathy involving the necrosis of the renal papilla. The aim of this case is theevaluation of histopathological changes in kidney and urinary bladder caused by urolithiasis with sitruvite, a pathologycommonly seen in dogs. Renal papillary necrosis that encountered in the case was evaluated histopathologically. We intendto discuss the relationship between urolithiasis and renal papillary necrosis.Case: The material of the case was a 7.5 year-old Rottweiler female dog that had been operated for the urolithiasis treatment and died after surgery. The animal sent to pathology department was necropsied and evaluated histopathologically.Also the uroliths removed during the surgery were sent for analysis postoperatively. Qualitative composition of urolithswas determined by a series of chemical analyses in Department of Biochemistry. X-ray diffraction was performed as wellin General Directorate of Mineral Research and Exploration in the objective of result verification. Macroscopically, 30pieces uroliths with varying size from 1 mm to 3 cm were seen in urinary bladder. They were 110 g in weight with smoothsurface and round and/or ovoid shapes. After necropsy, specimens from kidney and urinary bladder were fixed in 10%neutral buffered formalin, embedded in paraffin wax, cut at 5 μm, and stained with hematoxylin and eosin (HE). Bladderwall thickening and hemorrhage on mucosa were noticed. Kidneys had roughened surface with the capsule being difficultto peel off. Also, renal papillary necrosis, reddish in color was observed in papilla of the right kidney. Microscopically,crystal formations were observed proximal tubule lumens of kidneys. Interstitial nephritis...(AU)
Texto completo