Müllers duct persistence syndrome associated with cryptorchidism, Sertoli cell tumor and pyometra in a Miniature Schnauzer
Zambarda, Tais TeixeiraStefani, Renata QueirozSonne, LucianaPöppl, Álan Gomes
Background: Sexual development disturbances (SDD) are divided in SDD with XX genotype (SDD XX) and SDD withXY genotype (SDD XY). Among SDD XY, the Müllers duct persistence syndrome (MDPS) is characterized by XYkaryotype individuals with male external genitals; however, with internal female reproductive organs such as uterine horns,uterus, and cranial vagina portion. The MDPS cases and their related complications are considered very rare in veterinarymedicine. The aim of the present case report is to describe the clinical and pathological aspects of a MDPS case associatedwith cryptorchidism, Sertoli cell tumor, and pyometra in a Miniature Schnauzer dog.Case: A 7-year-old male Miniature Schnauzer weighting 7 kg was brought to veterinary consultation due to owners complain of frequent vomiting, apathy, abdominal algia and progressive scrotal enlargement in the last two months. Physicalexam reveals hyperthermia (39.7°C), discrete dehydration, enlarged popliteal lymph nodes as well as scrotum enlargementwith only one palpable testicle. A blood sample collected for complete blood count showed regenerative anemia, thrombocytopenia, and neutrophilia with left shift in the leukogram. Abdominal ultrasound examination indicated the presenceof a tubular structure filled by anechoic content extending from the scrotum to caudal abdomen. Moreover, a 6.39 x 8.54cm heterogeneous mass in the medial mesogastric region became evident. The patient was hospitalized and submittedto exploratory laparotomy after 24 h due to rectal temperature increase (41°C), worsened abdominal pain, and intenseapathy. There was free purulent liquid in abdominal cavity and two uterine horns were documented. The left uterine hornpasses through inguinal ring and both horns were filled by purulent material...(AU)
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