Carcinoma de células escamosas vaginal em uma vaca Nelore
Paula, Juliana Paniago Lordello dePupin, Rayane Chitolina
Background: Skin tumors are the most common neoplasia in veterinary medicine and squamous cell carcinoma (SCC)is the most frequent. In cattle, it is the main tumor besides linfosarcoma and normally affects taurine cattle, but is rarein Nelore cattle. SCC mainly affects mucocutaneous junctions such as the eyelids, sclera, vulva, and perineum, and hasalready been described in vagina, eye, and periocular tissues, in addition to the superior digestive tract. The purpose ofthis paper is to describe a vaginal squamous cell carcinoma in a Nelore cow.Case: A 10-year-old Nelore cow, used as an embryo donor, was submitted to a necropsy procedure. Clinically, the animalhad prolonged recumbency, anorexia, weight loss, and vaginal discharge. There was a history of recurrent vaginal prolapses and an intraluminal vaginal mass that had grown over two years. At necropsy, there was diffuse fibrinous peritonitiswith marked intestinal adhesions; the vagina was markedly expanded and measured 40 × 20 cm due to the presence of anintraluminal mass occupying the vestibulum and extending up to the cervix. In the vaginal lumen, there was large amountof fibrinonecrotizing malodorous material; the vaginal wall was thickened by an unencapsulated and poorly delimited,firm and white mass composed of sheets and nests of epithelial cells from the squamous layer surrounded by abundantfibrovascular stroma. The neoplastic cells were polygonal with marked pleomorphism, anisokaryosis, and anisocytosis;abundant eosinophilic and well-defined cytoplasmic borders. Sometimes it was possible to see desmosomes. The nucleiwere rounded to oval with sparse chromatin and one or more nucleoli were seen. Mitotic figures were frequent (at least3 per higher power field) and there were also a few multinucleated cells. Frequently, there was the formation of distinctkeratin pearls.Discussion: SCC frequently occurs in the skin...(AU)
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