Evaluation of total oxidant / antioxidant capacity and ceruloplasmin levels in horses with Inflammatory Airway Disease
Arslan, Handan HilalGenc, OktayCenesiz, MetinArslan, AliGenc, EvrimCenesiz, Sena
Background: Respiratory disease negatively affects the physiological performance of racehorses. Inflammatory Airway Disease (IAD) is a typical respiratory disease that affects young horses. The pathogenesis of IAD remains incompletely defined but it is thought to be associated with the inhalation of irritants such as barn dust and air pollution. Although noninfectious agents are likely to be central to the development of IAD, infectious agents can be associated with the disease. The main objective of the present study was to determine the relationships between IAD and antioxidant capacity, ceruloplasmin levels and bacterial and fungal infection status, in racehorses. Materials, Methods & Results: In this study, 25 thoroughbred race horses with exercise intolerance and respiratory system symptoms were evaluated as the study group and 10 healthy horses were included in the control group. Clinical examinations, endoscopic evaluation and tracheal lavage were administered to all horses. Mucus accumulation in the trachea was scored and the horses having a mucus score of ≥ 3 were included the study group. Tracheal lavage fluids were investigated to determine the microbiological status of all animals. In addition, blood samples were collected and total oxidant capacity (TOC), total antioxidant capacity (TAC) and ceruloplasmin (Cp) levels were determined with a spectroscopic method. Exercise intolerance and various respiratory system symptoms such as coughing, nasal discharge and noisy breathing, were the common findings from horses in the study group. Fungal culture was negative and only Streptococcus equi subsp. zooepidemicus strain was isolated from 6 samples. No statistical difference was determined between the TOC, TAC and Cp levels of the groups (P > .05).[...](AU)
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