Hepatoprotective effects of ginseng in rats fed cholesterol rich diet
Uluısık, DenizKeskin, Ercan
Background: Ginseng species having been used in various traditional herbal therapies for many years in worldwide. In recent years, hyperlipidemia, hypercholesterolemia and obesity have become serious health problems. These are considered risk factor for metabolic and organic diseases such as atherosclerosis, fatty liver, diabetes. Therefore, prevention and treatment of these disorders are significant for ensuring comfortable and healthy life. It has been also stated that ginseng saponin suppressed liver enzyme increments caused by feeding with high cholesterol or fatty diet. The present study was undertaken to evaluate the effect of ginseng on liver enzymes of rats fed cholesterol-rich diet. Materials, Methods & Results: In this study, 24 healthy adult male Wistar Albino rats were equally divided into three groups as control group (K), cholesterol group (C), and cholesterol + ginseng group (CG). The K group had ad libitum access to a standard rat diet for 40 days. The C and CG groups had ad libitum access to the same diet containing 5% cholesterol powder and 5% cholesterol + 1 g/kg Panax ginseng root powder, respectively, for 40 days. On the 40 th day of the study, blood samples were taken from 8 animals in each group. At the end of the study, plasma samples were analyzed for aspartase transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and [...](AU)
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