Intoxication by lornoxicam in two dogs
Albuquerque, Alice Ribeiro Oliveira LimaVeloso, Jéssica FontesCalazans, Ana Paula FernandesCarlos, Renata Santiago Alberto
Background: The indiscriminate use of drugs is routinely observed in the field of veterinary medicine. Nonsteroidal antiinflammatory drugs (NSAIDs) are the class of drugs that most commonly cause intoxication in pet animals. Lornoxicam, an NSAID, is a cyclooxygenase COX-1 and COX-2 inhibitor and is only recommended for human treatment. Here we present cases involving two dogs who presented with Lornoxicam intoxication following administration without veterinary prescription. Cases: 1) - A 1-year-old female Rottweiler was presented for clinic with claudication, profuse vomiting, and fetid blackish diarrhea. The owner reported administer two tablets of oral Lornoxicam. Physical examination revealed lethargy, a bulging abdomen and pale mucous membranes. Contrast-enhanced imaging of the gastrointestinal tract revealed decreased stomach flow. The ultrasound revealed predominantly gaseous contents in the stomach with normal walls, a large amount of accumulated gas in the pyloric region. Therefore, exploratory laparotomy was held and a nonperforated ulcer was observed in the pyloric region. There were hemorrhagic areas in the stomach mucosa and enlarged lymph nodes in the duodenum. The ulcer was resected without complications. Medications included after surgery were intravenous fluid, antibiotic, analgesic, antiemetic, histamine H2-receptor antagonist and Cytoprotective drugs. The day [...](AU)
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