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Periódicos Brasileiros em Medicina Veterinária e Zootecnia

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  3. Acta Scientiae Veterinariae
  4. Vol. 43 (2015) - Fascículo único
p. 1-7

Acute-phase protein profile of healthy bitches in diestrus: the influence of steroid hormones

Vannucchi, Camila InfantosiLúcio, Cristina de FátimaRegazzi, Fernanda MachadoAngrimani, Daniel de Souza RamosBrito, Maíra MoralesAbreu, Renata de Azevedo

Background: Acute-phase proteins are known as significant indicators of inflammation for several animal species, allowing more accurate follow-up of diseases, particularly when other clinical signs are not apparent. Nevertheless, the difficulty of data interpretation due to the absence of reference values for canine species represents an imperative obstacle for systematic clinical application. Moreover, no influence of hormonal status has yet been established for dogs. The aim of this study was thus to propose reference values of fibrinogen, haptoglobin, ceruloplasmin, seromucoid and glycoprotein for diestrous healthy females and therefore verify the influence of the hormone status.Materials, Methods & Results: Data consisted of weekly blood sampling from 20 Great Dane diestrous bitches during 9 weeks. Each animal’s health condition was verified through physical assessment and the absence of acute inflammatory or infectious processes was guaranteed by a total white cell count. Sampling started with diestrus onset and continued until the beginning of anestrus, evaluated by vaginal cytology. From blood samples, the concentrations of fibrinogen, haptoglobin, ceruloplasmin, seromucoid, glycoprotein, progesterone and estrogen were determined accordingly. No statistical variations (P < 0.05) on plasmatic fibrinogen, serum haptoglobin and ceruloplasmin concentrations were observed between weeks of diestrus nor a correlation between the hormonal profile. Significant increase in seromucoid concentration was verified between the 1st and 6th week of diestrus, while significant variation (P < 0.05) of glycoprotein was measured between the 1st and 3rd weeks of diestrus, as well as between weeks 2 and 9. The reference values proposed were: 182.22 (±46.40) mg/ dL for fibrinogen, 80.22 (±9.80) mg/dL of HbCN binding capacity for haptoglobin, 8.19 (±1.68) IU/L for ceruloplasmin, 79.88 (±15.78) mg/dL for seromucoid and 11.89 (±0.92) % for glycoprotein.[...](AU)

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