Effects of Lansberg’s hognose pit vipers (Porthidium lansbergii hutmanni) venom on renal ultrastructure in experimental mice

Vargas, AlbaFinol, HéctorGirón, MaríaScannone, HéctorFernández, IrmaRodriguez-Acosta, Alexis

Porthidium lansbergii hutmanni species occurs at Tropical level (800 meters altitude) in Margarita Island, Venezuela. It seems to be constrained to this island. Two different species; Porthidium lansbergii rozei and P. lansbergii lansbergii live in the mountains surrounding the Cordillera de La Costa in mainland Venezuela. The principal damage and the main complication in fatal cases of Viperidae snakebites in Venezuela is acute renal failure (ARF) secondary to acute tubular necrosis. Kidney alterations in Porthidium snakebite human victims have concerned inconspicuous considerations. There is not literature description of Porthidium venom activity on the renal structure. The purpose of this study was to determine how intraperitoneal Porthidium lansbergii hutmanni venom injection into mice could lead to severe renal injury.[...](AU)

1. proximal convoluted tubule
2. envenoming
3. kidney
4. glomeruli
5. venom
6. Porthidium lansbergii hutmanni
7. snakebite