Light-emitting diode stimulates radiodermatitis recovery
Laboratory of Microsurgery and Plastic SurgeryCamargo, Cristina PiresDepartment of Radiology and OncologyCarvalho, Heloisa AndradeDepartment of Radiology and OncologyMaluf, Feres CamargoLaboratory of Microsurgery and Plastic SurgerySousa, Alexandre Agostinho da CruzDepartment of Radiology and OncologyPerin, Paulo Otavio MalufPerin, Marcela MalufLaboratory of Microsurgery and Plastic SurgeryMorais-Besteiro, JulioLaboratory of Microsurgery and Plastic SurgeryGemperli, Rolf
ABSTRACT Purpose To evaluate the effect of light-emitting diode (LED) in an experimental model of radiodermatitis. Methods Ten male Wistar rats weighing 200-250 g were analyzed. Radiation was delivered in a single dose (20 Gy with Strontium-90 dermatological plaques), two areas per animal. After 15 days, they were divided into two groups: control group (n = 5) and LED group (n = 5), which was treated during 21 days later (LED 660 nm, 10 min in alternate days). The endpoints were radiodermatitis scale, histological analysis HE, Picrius Sirius and the gene expression of interleukin-10 (IL-10) and matrix metalloproteinase-9 (MMP-9). Results The LED group showed a higher number of dermal appendages (p = 0.04) and angiogenesis(p = 0.007), a tendency towards higher IL-10 (p = 0.06) and an increase in MMP-9 (p = 0.004) when compared to the control group. Conclusions This study suggested that the use of LED for radiodermatitis increased skin regeneration.
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