Influence of tramadol on functional recovery of acute spinal cord injury in rats

Chaves, Rosa Helena de Figueiredo; Souza, Celice Cordeiro de; Furlaneto, Ismari Perini; Teixeira, Renan Kleber Costa; Oliveira, Carolina Pinheiro de; Rodrigues, Emanuelle de Matos; Santos, Daniel Arthur Santos dos; Silva, Renata Cunha; Penha, Nelson Elias Abrahão da; Lima, Ana Rita de

p. 1087-1094

Influence of tramadol on functional recovery of acute spinal cord injury in rats

Chaves, Rosa Helena de FigueiredoSouza, Celice Cordeiro deFurlaneto, Ismari PeriniTeixeira, Renan Kleber CostaOliveira, Carolina Pinheiro deRodrigues, Emanuelle de MatosSantos, Daniel Arthur Santos dosSilva, Renata CunhaPenha, Nelson Elias Abrahão daLima, Ana Rita de

Purpose:To evaluate the influence tramadol on functional recovery of acute spinal cord injury in rats.Methods:Ten rats were divided into two groups (n = 5). All animals were submitted by a laminectomy and spinal cord injury at eighth thoracic vertebra. In control group, the rats didnt receive any analgesic. In tramadol group, the rats received tramadol 4mg/Kg at 12/12h until 5 days by subcutaneous. Animals were following by fourteen days. Was evaluated the Basso, Beattie, Bresnahan scale (locomotor evaluation) and Rat Grimace Scale (pain evaluation) at four periods.Results:There no difference between the groups in locomotor evaluation in all periods evaluated (p>0.05) and in both groups there was a partial recover of function. The tramadol group show a lower pain levels at the first, third and seventh postoperatively days when comparing to the control group.Conclusion:The tramadol as an analgesic agent dont influence on functional recovery of acute spinal cord injury in rats.(AU)