Acute systemic response to intraperitoneal implantation of polypropylene mesh/chitosan-based film composite in pigs

Martins, Apóstolo FerreiraBorges, Naida CristinaCoutinho, Priscila VazLemes, Aline RodriguesSilva, Ashbel Schneider daBarbosa, Rayssa KossaPaulo, Neusa Margarida

PURPOSE:To assess the systemic response of pigs to the intraperitoneal implantation of polypropylene mesh associated with chitosan-based film with a degree of deacetylation of 95%.METHODS:Blood samples were collected 24 hours before, and two and seven days after surgery. Systemic reactions were evaluated based on white blood cell count, C-reactive protein, and total serum protein, albumin and globulin levels.RESULTS:The systemic response was proportional to the composite response induced by polypropylene mesh, and the tissue inflammatory response was higher in the PP group (p=0.0033).CONCLUSION:The polypropylene mesh/chitosan-based film composite did not elicit a systemic response in pigs.

1. Swine
2. Surgical Mesh
3. Chitosan
4. Peritoneum