Acute systemic response to intraperitoneal implantation of polypropylene mesh/chitosan-based film composite in pigs

Martins, Apóstolo FerreiraBorges, Naida CristinaCoutinho, Priscila VazLemes, Aline RodriguesSilva, Ashbel Schneider daBarbosa, Rayssa KossaPaulo, Neusa Margarida

To assess the systemic response of pigs to the intraperitoneal implantation of polypropylene mesh associated with chitosan-based film with a degree of deacetylation of 95%. METHODS: Blood samples were collected 24 hours before, and two and seven days after surgery. Systemic reactions were evaluated based on white blood cell count, C-reactive protein, and total serum protein, albumin and globulin levels. RESULTS: The systemic response was proportional to the composite response induced by polypropylene mesh, and the tissue inflammatory response was higher in the PP group (p=0.0033). CONCLUSION: The polypropylene mesh/chitosan-based film composite did not elicit a systemic response in pigs.(AU)

1. Chitosan
2. Peritoneum
3. Surgical Mesh
4. Swine