An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation

Migliavacca, Raphaella de OliveiraPiltcher, Otávio BejzmanKliemann, Lúcia MariaCerski, Marcelle ReesinkMeyer, FabíolaOppermann, Paula de OliveiraMachado Filho, GeraldoKang, Suzie HyeonaCosta, Sady Selaimen da

Evaluate and compare two different experimental techniques of maxillary sinus ostium occlusion using N-butyl cyanoacrylate in developing chronic histological findings without the inoculation of pathogenic bacteria among rabbits. In a randomized study, sixteen New Zealand rabbits were assigned for occlusion of the right maxillary sinus through a transmaxillary approach or through the roof of the nasal cavity. The contralateral sinus served as a control. After 12 weeks, the animals were sacrificed for blinded histopathological analysis of the maxillary sinus mucosa. Histopathological changes consistent with CRS were found in eight (100%) of the maxillary sinuses approached transmaxillary and three of those through the roof of the nasal cavity (37.5%), p 0.008 and 0.250, respectively, comparing with the control side. Chronic mucosal changes were significantly better induced using the transmaxillary approach (p 0.026). It is possible to induce a model of chronic sinusitis among rabbits with transmaxillary sinus occlusion without bacterial inoculation. This model can be replicated for future cellular studies.(AU)

1. Maxillary Sinusitis
2. Models, Animal
3. Sinusitis
4. Disease Models, Animal
5. Rabbits