A standard burn model using rats

Meyer, Tufi NederSilva, Alcino Lázaro da

Experimental burn models are always needed, being essential for burn research. In the present study, we describe a standard Fischer F-344 rat burn model, in which burns are produced with a heated brass bar. The animals were anesthetized with ketamine (90 mg/kg). After the burns, they were resuscitated with saline. Burns ranging from 26 percent to 30percent of total body surface area resulted in a 62.5 percent mortality rate after 25 days. This model is an additional option for those interested in burn research