Peritoneal infection by Candida albicans: study of number and size of limphocytes and phagocitic activy of peritoneal machophages in mice

Saad, FlávioRegina R. da Silva, MariaHayashi, HisakazuF Gompertz, Olgade Araújo Segreto, RobertoRegina Comodo Segreto, HelenaLúcia B Mestriner, ClaraFerreira Novo, NeilJuliano, YaraPlapler, Hélio

The main purpose of this investigation was to stdy some aspects of leucocytes (granulocytes and limphocytes) and the phagocitic activity of peritoneal macrophages. In this experimen, which took place at Escola Paulista de Medicina - Universidade Federal de São Paulo - Brazil, it was used twenty female C57BLACK mice. Half of them were submitted to radiation to obtain immunossupressed animals (Group A - irradiated mice). The other ten mice were not iiradiated (Group B - control). The animals were sorted in four subgroups A-2 and B-2, were infected with Candida albicans (ATCC 90029). The resultant data showed significant differences in the number of leucocytes (granulocytes and limphocytes), and in the medium size of limphocytes between irradiated and non irradiated mice. Related to peritoneal macrophages, it was observed that the number of macrophages was lower in irradiated mice and the phagocitic was decreased in the irradiated and infected animals.

1. Peritonitis
2. Macrophages
3. Leucocytes
4. Candida albicans
5. Ionizing radiation